RNA interference: From gene silencing to gene-specific therapeutics
نویسندگان
چکیده
منابع مشابه
RNA interference: from gene silencing to gene-specific therapeutics.
In the past 4 years, RNA interference (RNAi) has become widely used as an experimental tool to analyse the function of mammalian genes, both in vitro and in vivo. By harnessing an evolutionary conserved endogenous biological pathway, first identified in plants and lower organisms, double-stranded RNA (dsRNA) reagents are used to bind to and promote the degradation of target RNAs, resulting in k...
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Over the past two decades, dramatic advances in the role of RNA in normal health and disease have been greatly expanded. During development Small RNA molecules regulate eukaryotic gene expression and also during responses to stress including viral infection. RNA interference (RNAi) is a highly conserved process in eukaryotes that leads to post-transcriptional gene silencing through degradation ...
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Discovered only in the last ten years, RNA interference is a powerful tool that can be used to silence any gene of interest in many biological systems. To date, this technology has been used largely for research applications, involving cells grown in the laboratory or model organisms, as well as new therapeutics for cancer. Multi-disciplinary teams are involved to develop this technology forwar...
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ژورنال
عنوان ژورنال: Pharmacology & Therapeutics
سال: 2005
ISSN: 0163-7258
DOI: 10.1016/j.pharmthera.2005.03.004